PROTAC EGFR degrader 5 [2409793-36-6]
HY-146422
CAS Number2409793-36-6
Product group Chemicals
Molecular Weight1070.33
Overview
- SupplierMedChem Express
- Product NamePROTAC EGFR degrader 5 [2409793-36-6]
- Delivery Days Customer10
- CAS Number2409793-36-6
- CertificationResearch Use Only
- Molecular FormulaC57H72FN13O5S
- Molecular Weight1070.33
- Scientific DescriptionPROTAC EGFR degrader 5 (Compound 10), a PROTAC EGFR degrader, potently degrades EGFRDel19 in HCC827 cells with the DC50 of 34.8 nM. PROTAC EGFR degrader 5 significantly induces the apoptosis of HCC827 cells and arrest the cells in G1 phase[1].
- SMILESCC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCCCCCN4CCN(CC4)C5=CC=C(N=C5)NC6=NC=C7N=C(N=C(C7=C6)N8CCC(CC8)CO)NC9=CC=C(C=C9)F)=O)=O)O)=O
- UNSPSC12131703