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PROTAC EGFR degrader 7

HY-147858
MedChem Express
Estimated Purity99.99
Product group Chemicals
Molecular Weight836.94
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Overview

  • Supplier
    MedChem Express
  • Product Name
    PROTAC EGFR degrader 7
  • Delivery Days Customer
    5
  • Certification
    Research Use Only
  • Estimated Purity
    99.99
  • Molecular Formula
    C46H48N10O6
  • Molecular Weight
    836.94
  • Scientific Description
    PROTAC EGFR degrader 7 (compound 13b) is a potent and selective CRBN-recruiting PROTAC EGFRL858R/T790M degrader, with a DC50 of 13.2 nM. PROTAC EGFR degrader 7 inhibits NCI-H1975 cells proliferation, with an IC50 of 46.82 nM. PROTAC EGFR degrader 7 significantly induces apoptosis and G2/M phase arrest in NCI-H1975 cell. PROTAC EGFR degrader 7 shows antitumor activity, and can be used for non-small cell lung cancer (NSCLC) research[1]. PROTAC EGFR degrader 7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
  • SMILES
    C#CCN(CCN(C1=CC(OC)=C(C=C1NC(C=C)=O)NC2=NC(C3=CN(C4=CC=CC=C34)C)=CC=N2)C)CCCC(NC5=C6CN(C(C6=CC=C5)=O)C7CCC(NC7=O)=O)=O
  • Storage Instruction
    -20°C
  • UNSPSC
    12131703