PROTAC ERalpha Degrader-5 [2158322-33-7]

MedChem Express

PROTAC ERalpha Degrader-5 [2158322-33-7]

10

2158322-33-7

Research Use Only

98.96

C94H107N13O16

1674.93

PROTAC ERalpha Degrader-5 (compound LP2) consists an ADC linker and a PROTAC, whcih can be conjugated to an antibody to form PACs. PROTAC ERalpha Degrader-5 conjugated to an antibody is a more marked estrogen receptor-alpha (ERalpha) degrader compared to PROTAC (without Ab)[1].

CN(C(COCCOCCNC(C1=CC=C(C(N2[C@@H](C)[C@H](NC([C@H](C)NC)=O)C(N(CC3=C(OC)C=CC4=C3C=CC=C4)C5=C2C=C(C#N)C=C5)=O)=O)C=C1)=O)=O)CCOC(C=C6)=CC=C6/C(C7=CC=C(OCC(C=C8)=CC=C8NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN9C(C=CC9=O)=O)=O)=O)=O)C=C7)=C(C%10=CC=CC=C%10)/CC

-20°C

41115800