PROTAC_ERRalpha [1801547-15-8]

MedChem Express

PROTAC_ERRalpha [1801547-15-8]

10

1801547-15-8

Research Use Only

99.71

C46H47F3N6O9S2

949.03

PROTAC_ERRalpha is a potent and selective ERRalpha PROTAC degrader (DC50: 100 nM in MCF-7 cells). PROTAC_ERRalpha induces proteasomal degradation and has capable of specifically degrading ERRalpha protein by >80%. Blue: VHL ligand (HY-125845), Pink: ERRalpha ligand (HY-U00425), black: linker[1].

O=C(/C(SC1=O)=C/C2=CC(OC)=C(C=C2)OC3=C(C=C(C=C3)C#N)C(F)(F)F)N1CCOCCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@H](C4)O)C(NCC5=CC=C(C6=C(N=CS6)C)C=C5)=O)=O)=O

-20°C,2°C to 8°C

12131703