PROTAC HPK1 Degrader-4

MedChem Express

PROTAC HPK1 Degrader-4

999

Research Use Only

C46H46N8O5

790.91

PROTAC HPK1 Degrader-4 (compound E3) is a selective and orally active PROTAC HPK1 degrader with a DC50 of 3.16 nM. PROTAC HPK1 Degrader-4 demonstrates >1000-fold selectivity over GLK. PROTAC HPK1 Degrader-4 promotes immune activation. PROTAC HPK1 Degrader-4 can be used for the study of colon cancer and lymphoma (Pink: ligand for target protein (HY-174355); Blue: ligand for E3 ligase CRBN (HY-45808); Black: Linker (HY-174356); Target protein ligand-linker Conjugate (HY-174357))[1].

O=C1N(C(C2=CC(N3CC(C3)CN4CC=C(CC4)C5=C(C=C(C=C5C)C6=NC7=C(N=C6)NC=C7C8=CC(C)=C(C=C8)C(N(C)C)=O)C)=CC=C21)=O)C9C(NC(CC9)=O)=O

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