PROTAC K-Ras Degrader-4

MedChem Express

PROTAC K-Ras Degrader-4

9

Research Use Only

99.01

C50H60N12O6S2

989.22

PROTAC K-Ras Degrader-4 (Compound 4) is a PROTAC degrader for KRAS that degrades KRASG12D in GP5d and degrades KRASG12V in cell SW620 with DC50s of 1 nM and 13 nM. PROTAC K-Ras Degrader-4 inhibits MAPK signaling pathway[1]. (Pink: ligand for target protein pan-KRAS degrader 1 (HY-162960); Black: linker (HY-159790); Blue: ligand for E3 ligase VHL (HY-W998248))

C[C@@]1(C2=NC(C3=NC(N4[C@H](CN(CCC4)CCCCOC5=NOC([C@@H](C(C)C)C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C8=C(N=CS8)C)C=C7)=O)=O)=C5)C)=NC=C3)=NO2)C9=C(CCC1)SC(N)=C9C#N

-20°C,2°C to 8°C

12352200