PROTAC MPS1 degrader 2

MedChem Express

PROTAC MPS1 degrader 2

9

Research Use Only

C41H41N11O8S

847.90

PROTAC MPS1 degrader 2 (Compound 15) is a potent degrader of monopolar spindle 1 (Mps1, TTK), AURKA and AURKB, with DC50s of 42.0, 2.1 and 154.0 nM, respectively. PROTAC MPS1 degrader 1 can be used for the research of acute myeloid leukemia. (Pink: ligand for target protein (HY-168545); Black: linker (HY-N0420); Blue: ligand for E3 ligase (HY-10984)[1].

O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCC(N4CCN(C5=CC=C(NC6=NC(NC7=CC=CC=C7S(=O)(C(C)C)=O)=C8N=CNC8=N6)C=C5)CC4)=O

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