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PROTAC PARP1 degrader-3

HY-168722
MedChem Express
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    PROTAC PARP1 degrader-3
  • Delivery Days Customer
    5
  • Certification
    Research Use Only
  • Scientific Description
    PROTAC PARP1 degrader-3 (Compound C6) is a PROTAC degrader for PARP1 with a DC 50 of 58.14 nM. PROTAC PARP1 degrader-3 exhibits cytotoxicity in cancer cell SW-620 and LOVO with IC 50 of 1.63 microM and 2.84 microM. PROTAC PARP1 degrader-3 exhibits a synergistic effect with SN-38 (HY-13704) in BRCA-mutated colon cancer cell with a combination index (CI) of 0.487. (Blue: Ligand for E3 ligase Cereblon (HY-23095); Pink: Ligand for target protein (HY-10619); Black: Linker (HY-16872)) [1]
  • UNSPSC
    12352200