PROTAC SARS-CoV-2 Degrader-1

MedChem Express

PROTAC SARS-CoV-2 Degrader-1

999

Research Use Only

C40H37ClFN7O10

830.21

PROTAC SARS-CoV-2 Degrader-1 (Compound LLP019) is a SARS-CoV-2 MPro PROTAC degrader with a DC50 value of 4.7 microM. PROTAC SARS-CoV-2 Degrader-1 induces MPro ubiquitination and proteasomal degradation to inhibit SARS-CoV-2 replication. PROTAC SARS-CoV-2 Degrader-1 is promising for research of COVID-19 and related coronavirus infections. (Pink: DH03 (HY-32717); Black: linker (HY-42149); Blue: Thalidomide-4-O-CH2-COO(t-Bu) (HY-42771)[1].

CCOC1=C(NC(CCOCCOCCNC(COC2=C(C(N(C3CCC(NC3=O)=O)C4=O)=O)C4=CC=C2)=O)=O)C=C(C(NC5=CC(Cl)=C(F)C=C5)=C(C#N)C=N6)C6=C1

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