PROTAC SARS-CoV-2 Mpro degrader-3

MedChem Express

PROTAC SARS-CoV-2 Mpro degrader-3

5

Research Use Only

C53H73N10NaO14S2

1161.33

PROTAC SARS-CoV-2 Mpro degrader-3 (Compound P2) exhibits antiviral activity through the degradation of the main protease (Mpro) of human coronaviruses (HCoVs) (DC50=27 microM). PROTAC SARS-CoV-2 Mpro degrader-3 inhibits the viral replication, with EC50 of 4.6 microM, 4.6 microM, and 0.71 microM, for human coronaviruses HCoV-229E, HCoV-OC43 and SARS-CoV-2, respectively. (Pink: ligand for target protein Mpro ligand 2 (HY-161791); Black: linker (HY-161792); Blue: ligand for E3 ligase (S,R,S)-AHPC (HY-125845)) [1].

O=C(N[C@@H](C(C)(C)C)C(N1C[C@H](O)C[C@H]1C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)=O)COCCCCCN4N=NC(COC5=CC=C(COC(N[C@H](C(N[C@@H](C[C@@H]6CCNC6=O)C(O)S(=O)(O[Na])=O)=O)CC(C)C)=O)C=C5)=C4

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