PROTAC SGK3 degrader-1

MedChem Express

PROTAC SGK3 degrader-1 [2381320-35-8]

10

2381320-35-8

Research Use Only

99.89

C57H73FN10O11S2

1157.38

PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a von Hippel-Lindau ligand-based SKG3 PROTAC composed of a PEG3-C4-OBn (HY-130620) alkyl linker, an SGK3 degrader (red structure), and a VHL ligand (HY-150803, blue structure). PROTAC SGK3 degrader-1 (0.3 microM) induced 50% endogenous SGK3 degradation within 2 hours, and 80% SGK3 degradation was observed at 8 hours, accompanied by loss of phosphorylation of NDRG1 (SGK3 substrate) [1] .

FC1=C(C=C(C=C1)C)S(=O)(NC2=CC=C(C=C2)C3=NC4=C(C(OC[C@H]5CN(CCO5)CCCCCCOCCOCCOCC(N[C@H](C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C=C7)C8=C(N=CS8)C)=O)=O)C(C)(C)C)=O)=N3)C=NN4)=O

-20°C

12352200