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PROTAC Sirt2 Degrader-1 [2098487-75-1]

HY-103636
MedChem Express
CAS Number2098487-75-1
Product group Chemicals
Estimated Purity98.5%
Molecular Weight852.94
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Packing Size
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Overview

  • Supplier
    MedChem Express
  • Product Name
    PROTAC Sirt2 Degrader-1 [2098487-75-1]
  • Delivery Days Customer
    10
  • CAS Number
    2098487-75-1
  • Estimated Purity
    98.5%
  • Molecular Formula
    C40H40N10O8S2
  • Molecular Weight
    852.94
  • Scientific Description
    PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide Cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 microM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s>100 microM).
  • SMILES
    O=C(N(C(CCC1=O)C(N1)=O)C2=O)C(C2=CC=C3)=C3OCC(NCCCCN4C=C(COC5=CC(CC6=CN=C(NC(CSC7=NC(C)=CC(C)=N7)=O)S6)=CC=C5)N=N4)=O
  • Storage Instruction
    -20°C,-80°C
  • UNSPSC
    12352200