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PROTAC(r) Optimization Kit for CDK Kinase-Cereblon Binding

PROTAC(r) Optimization Kit for CDK Kinase-Cereblon Binding

Research Use Only
79924
BPS Bioscience
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More than 130 suppliers
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Overview

  • Supplier
    BPS Bioscience
  • Product Name
    PROTAC(r) Optimization Kit for CDK Kinase-Cereblon Binding
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Scientific Description
    The PROTAC Optimization Kit for CDK Kinase-Cereblon Binding is designed for testing and profiling of PROTACs directed against the CDK Kinase family and Cereblon. Cereblon (CRBN) is a Substrate recognition component of the DCX (DDB1-CUL44-Rbx1) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The CDK inhibitor Palbociclib is included as a control inhibitor of PROTAC binding to CDK. With this kit, only three simple steps on a microtiter plate are required for PROTAC activity detection. First, a sample containing PROTAC is incubated with CRBN and CDK4 or CDK6 Kinase. Next, acceptor beads are added, then donor beads, followed by reading the Alpha-counts.
  • UNSPSC
    41116133