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Mouse CD155, Mouse IgG2a Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Immobilized Mouse TIGIT, His Tag (Cat. No. TIT-M52E6) at 10 μg/mL (100 μL/well) can bind Mouse CD155, Mouse IgG2a Fc Tag (Cat. No. CD5-M5254) with a linear range of 0.039-1.25 μg/mL (QC tested).

CD5-M5254 | Mouse CD155 / PVR Protein, Mouse IgG2a Fc Tag | AcroBiosystems products available at Bio-Connect

Mouse CD155 / PVR Protein, Mouse IgG2a... | CD5-M5254 | AcroBiosystems

Mouse CD155 / PVR Protein, Mouse IgG2a Fc Tag

Molecular Biology

Characteristics: This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 61.8 kDa. The protein migrates as 35 kDa and 70-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. Description: CD155 is a Type I transmembrane glycoprotein in the immunoglobulin superfamily. Commonly known as Poliovirus Receptor (PVR) due to its involvement in the cellular poliovirus infection in primates, CD155's normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155/PVR was originally isolated based on its ability to mediate polio virus attachment to host cells. The fulllength (or CD155 alpha isoform) is synthesized as a 417 amino acid (aa) precursor that contains a 20 aa signal sequence, a 323 aa extracellular region, a 24 aa TM segment and a 50 aa cytoplasmic tail. The extracellular region contains one N terminal V type and two C2 type Ig like domains. CD155 is a transmembrane protein with 3 extracellular immunoglobulin-like domains, D1-D3, where D1 is recognized by the virus. Low resolution structures of CD155 complexed with poliovirus have been obtained using electron microscopy while a high resolution structures of theectodomain D1 and D2 of CD155 were solved by x-ray crystallography.

Rhesus macaque LAIR-1, Mouse IgG2a Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Immobilized Human Collagen I protein at 2 μg/mL (100 μL/well) can bind Rhesus macaque LAIR-1, Mouse IgG2a Fc Tag (Cat. No. LA1-C52A3) with a linear range of 5-78 ng/mL (QC tested).

LA1-C52A3 | Rhesus macaque LAIR-1 / CD305 Protein, Mouse IgG2a Fc Tag | AcroBiosystems products available at Bio-Connect

Rhesus macaque LAIR-1 / CD305 Protein,... | LA1-C52A3 | AcroBiosystems

Rhesus macaque LAIR-1 / CD305 Protein, Mouse IgG2a Fc Tag

Characteristics: This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 42.9 kDa. The protein migrates as 64 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. Description: Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell–mediated cytotoxicity. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.Diseases associated with LAIR1 include Chronic Active Epstein-Barr Virus Infection and Palindromic Rheumatism.

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