Protosappanin A [102036-28-2]

TargetMol Chemicals

Protosappanin A [102036-28-2]

9

102036-28-2

Research Use Only

Protosappanin A

C15H12O5

272.25

Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IIB/NF-IB inflammation signal pathway; it exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia. Protosappanin A induces immunosuppression of rats heart transplantation targeting T cells in grafts via NF-kappaB pathway. Protosappanin A and protosappanin B have antimicrobial activity, they show both alone activities and resistance reversal effects of amikacin and gentamicin against MRSA. Protosappanin A shows strong effect against HIV-1 IN with an IC50 value of 12.6 uM.

3 years

Oc1ccc-2c(OCC(=O)Cc3cc(O)c(O)cc-23)c1

-20°C

12352200