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Western Blot analysis of 293T cell using PRPS1/2/PRPS1L1 Polyclonal Antibody at dilution of 1:400
Western Blot analysis of 293T cell using PRPS1/2/PRPS1L1 Polyclonal Antibody at dilution of 1:400
Western Blot analysis of 293T cell using PRPS1/2/PRPS1L1 Polyclonal Antibody at dilution of 1:400

PRPS1/2/1L1 Polyclonal Antibody

Research Use Only
E-AB-15944
Elabscience
Product group Antibodies
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Overview

  • Supplier
    Elabscience
  • Product Name
    PRPS1/2/1L1 Polyclonal Antibody
  • Delivery Days Customer
    12
  • Applications Supplier
    ELISA WB IHC
  • Certification
    Research Use Only
  • Concentration
    0.4mg/ml
  • Scientific Description
    PRPS (phosphoribosyl pyrophosphate synthetase) proteins catalyze the synthesis of phosphoribosyl pyrophosphate (PRPP). Three human PRPS isoforms exist and are encoded by three different genes. PRPS1 and PRPS2 (also known as PRS1 and PRS2, respectively) are ubiquitously expressed, while PRPS3 (also known as PRPS1L1) is specific to the testis. PRPP is an important substrate synthesized from MgATP and ribose-5-phosphate in a reaction that requires inorganic phosphate and magnesium as a cofactor. PRPP is essential in the synthesis of nearly all nucleotides, implying that PRPS1/2 play an important role in nucleotide biosynthesis and purine metabolism. A mutation in the gene encoding PRPS1 may result in PRPS superactivity, a disease characterized by gout and the overproduction of purine nucleotides, uric acid and PRPP. PRPS1 mutations can also lead to a reduction in PRPS1 activity resulting in ARTS syndrome or CMTX5 (Charcot-Marie-Tooth disease X-linked recessive type 5).
  • UNSPSC
    12352203