Bio-Connect

PRT-060318 [1194961-19-7]

HY-12974
MedChem Express
CAS Number1194961-19-7
Product group Chemicals
Estimated Purity99.59
Molecular Weight340.42
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Overview

  • Supplier
    MedChem Express
  • Product Name
    PRT-060318 [1194961-19-7]
  • Delivery Days Customer
    10
  • CAS Number
    1194961-19-7
  • Certification
    Research Use Only
  • Estimated Purity
    99.59
  • Hazard Information
    h302-h315-h319-h335,p261-p264-p270-p271-p280-p302+p352-p304+p340-p305+p351+p338-p330-p362+p364-p403+p233-p405-p501
  • Molecular Formula
    C18H24N6O
  • Molecular Weight
    340.42
  • Scientific Description
    PRT-060318 (PRT318) s a potent, selective and orally active tyrosine kinase Syk inhibitor with an IC50 of 3 nM. PRT-060318 suppresses chronic lymphocytic leukemia (CLL) B cell activation and migration, and induces apoptosis. PRT-060318 prevents Heparin (HY-17567)-induced thrombocytopenia and thrombosis in a transgenic mouse model. PRT-060318 dihydrochloride can be used for CLL and thrombus research[1][2].
  • SMILES
    O=C(C1=CN=C(N[C@H]2[C@@H](N)CCCC2)N=C1NC3=CC=CC(C)=C3)N
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200