PRT4165 --- E3 Ubiquitin-ligase Bmi1/Ring1A Inhibitor

Bioss

PRT4165 --- E3 Ubiquitin-ligase Bmi1/Ring1A Inhibitor

16

Research Use Only

98.0

PRT4165 is a small molecule inhibitor of polycomb repressive complex 1, which inhibits ubiquitin signaling at DNA double-strand breaks. PRT4165 is a potent inhibitor of PRC1-mediated H2A ubiquitylation in vivo and in vitro. The drug also inhibits the accumulation of all detectable ubiquitin at sites of DNA double-strand breaks (DSBs), the retention of several DNA damage response proteins in foci that form around DSBs, and the repair of the DSBs.

-20°C

51202000