PRTFDC1 antibody

GeneTex

PRTFDC1 antibody

9

WB: 1 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

PRTFDC1

phosphoribosyl transferase domain containing 1

HHGP, phosphoribosyltransferase domain-containing protein 1

Rabbit

IgG

Phosphoribosyltransferase domain-containing protein 1

Phosphoribosyl transferase domain containing 1 (PRTFDC1) is highly homologous to the hypoxanthine phosphoribosyltransferase (HPRT1) and may have arisen from a gene duplication event of a common ancestor gene. Recently, it was shown that CpG islands in the PRTFDC1 promoter could be hypermethylated in ovarian cancers and oral squamous-cell carcinomas (OSCC), leading to gene silencing. Restoration of PRTFDC1 expression in OSCC inhibited cell growth in colony-formation assays, while knockdown of PRTFDC1 expression in OSCC that expressed the gene promoted cell growth. These results suggest that PRTFDC1 can act as a tumor-suppressor gene. At least three isoforms of PRTFDC1 are known to exist.

-20°C or -80°C,2°C to 8°C

12352203