Prucalopride (succinate)

MedChem Express

Prucalopride (succinate) [179474-85-2]

10

179474-85-2

Research Use Only

99.95

C22H32ClN3O7

485.96

Prucalopride succinate is an orally active, selective and specific 5-HT 4 receptor agonist (high affinity), with pK i s of 8.6 and 8.1 for human 5-HT4a/4b receptors , respectively. Prucalopride succinate improves intestinal motility by promoting regeneration of the intestinal nervous system in rats. Prucalopride succinate also shows anticancer activity by blocking of the PI3K/AKT/mTor signaling pathway. Prucalopride succinate can be used in studies of chronic constipation, pseudo-intestinal obstruction and cancer [1] [2] [3] [4] .

O=C(O)CCC(O)=O.O=C(C1=C(OCC2)C2=C(N)C(Cl)=C1)NC3CCN(CCCOC)CC3

2°C to 8°C

12352200