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PRX-07034 hydrochloride

PRX-07034 hydrochloride

T8720
TargetMol Chemicals
CAS Number903580-39-2
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Product group Chemicals
Molecular Weight490.44
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    PRX-07034 hydrochloride
  • Delivery Days Customer
    4
  • CAS Number
    903580-39-2
  • Category Supplier
    Chemical
  • Chemical Name
    PRX-07034 hydrochloride
  • Molecular Formula
    C21H29Cl2N3O4S
  • Molecular Weight
    490.44
  • Scientific Description
    PRX-07034 hydrochloride is a selective antagonist of 5-HT6 receptor. It has cognition and memory-enhancing properties and potently decreases food intake and body weight in rodents. PRX-07034 hydrochloride is both a potent (Ki = 4-8 nM) and highly selective 5-HT(6) receptor antagonist (≥100-fold selectivity for the 5-HT(6) receptor compared to 68 other GPCRs, ion channels, and transporters, except D(3) (Ki = 71 nM) and 5-HT(1B) (Ki = 260 nM) receptors.
  • Shelf life instruction
    3 years
  • SMILES
    Cl.COc1cc(Cl)cc(C(C)Nc2cc(ccc2S(C)(=O)=O)N2CCNCC2)c1OC
  • Storage Instruction
    -20°
  • UNSPSC
    12352200

References

  • Abraham R , Nirogi R , Shinde A , et al. Low-dose prazosin in combination with 5-HT6 antagonist PRX-07034 has antipsychotic effects[J]. Canadian Journal of Physiology & Pharmacology, 2015, 93(1):13-21.
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