PSB-10 (hydrochloride)

MedChem Express

PSB-10 (hydrochloride)

10

591771-91-4

Research Use Only

C16H15Cl4N5O

435.14

PSB-10 hydrochloride is a potent and selective antagonist of human adenosine A3 receptor (A3AR), with a Ki of 0.44 nM. PSB-10 hydrochloride shows more than 800-fold selectivity for hA3 over rA1, rA2A, hA1, hA2A and hA2B receptors (Ki=805, 6040, 1700, 2700, 30000 nM, respectively). PSB-10 hydrochloride produces thermal hyperalgesia in mice[1][2].

O=C1N(C)C2=C(N=C(C3=CC(Cl)=CC(Cl)=C3Cl)N2)C4=N[C@H](CC)CN14.[H]Cl

12352200