Pseudolaric Acid A

Selleck Chemicals

Pseudolaric Acid A [82508-32-5]

9

Research Use Only

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Pseudolaric acid A, a Hsp90 inhibitor with an IC50 of 0.60 microM, 2.72 microM, 1.36 microM, 2.92 microM and 6.16 microM in HL-60, A549, SMMC-7721, HeLa and SW480 cells respectively, is the main bioactive ingredient in Pseudolarix cortex, and induces cell cycle arrest at G2/M phase and promotes cell death through caspase-8/caspase-3 pathway, demonstrating potent antiproliferation and anticancer activities.

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