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ProductsBack/Pseudouridimycin [1566586-52-4]
Chemical Structure
Chemical Structure
Chemical Structure

Pseudouridimycin [1566586-52-4]

Research Use Only
AG-CN2-0316
AdipoGen Life Sciences
CAS Number1566586-52-4
DownloadMSDS
Product group Chemicals
Estimated Purity>85%
Molecular Weight486.4
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Pseudouridimycin
  • Delivery Days Customer
    10
  • CAS Number
    1566586-52-4
  • Certification
    Research Use Only
  • Estimated Purity
    >85%
  • Molecular Formula
    C17H26N8O9
  • Molecular Weight
    486.4
  • Scientific Description
    Chemical. CAS: 1566586-52-4. Formula: C17H26N8O9. MW: 486.4. Isolated from Streptomyces sp. Peptidyl nucleoside antibiotic. Selective nucleoside-analog inhibitor of bacterial RNA polymerase (RNAP). Inhibits RNAP through a distinctive binding site on RNAP (the NTP addition site) and mechanism (competition with UTP for occupancy of the NTP addition site) than Rifampin. Targets bacterial RNAP in Gram-positive and Gram-negative organisms, including antibiotic-resistant isolates and shows extremely low frequency of resistance selection. Potently inhibits bacterial RNAP in vitro, inhibits bacterial growth in culture, and has shown in vivo efficacy in animal models of infection. - Peptidyl nucleoside antibiotic. Selective nucleoside-analog inhibitor of bacterial RNA polymerase (RNAP). Inhibits RNAP through a distinctive binding site on RNAP (the NTP addition site) and mechanism (competition with UTP for occupancy of the NTP addition site) compared to rifampin. Targets bacterial RNAP in Gram-positive and Gram-negative organisms, including antibiotic-resistant isolates and shows extremely low frequency of resistance selection. Potently inhibits bacterial RNAP in vitro, inhibits bacterial growth in culture and has shown in vivo efficacy in animal models of infection.
  • SMILES
    O[C@H]1[C@H](C(C(N2)=O)=CNC2=O)O[C@H](CNC([C@H](CCC(N)=O)N(O)C(CNC(N)=N)=O)=O)[C@H]1O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase: S.I. Maffioli, et al.; Cell 169, 1240 (2017)
  • Pseudouridimycin: The First Nucleoside Analogue That Selectively Inhibits Bacterial RNA Polymerase: M.F. Chellat & R. Riedl; Angew. Chem. Int. Ed. Engl. 56, 13184 (2017)
  • Novel RNA polymerase inhibitor found in soil extracts provides hope for future antibacterial drugs: R.H. Ebright; Future Med. Chem. 9, 1857 (2017)