Pseudouridimycin [1566586-52-4]

MedChem Express

Pseudouridimycin [1566586-52-4]

10

1566586-52-4

Research Use Only

96.0

C17H26N8O9

486.44

Pseudouridimycin (PUM) is an antibiotic that selectively inhibits bacterial RNA polymerase (RNAP), with an IC50 of about 0.1 microM and MICs of 4-6 microg/mL. Pseudouridimycin is a C-nucleoside analogue thats effective against both Gram-negative and Gram-positive bacteria. Pseudouridimycin inhibits bacterial growth in vitro and shows activity in a mouse model of purulent streptococcal peritonitis[1][2].

O=C1NC(C([C@H]2[C@@H]([C@@H]([C@@H](CNC([C@H](CCC(N)=O)N(C(CNC(N)=N)=O)O)=O)O2)O)O)=CN1)=O

-20°C

12352200