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ProductsBack/PTAFR Polyclonal Antibody

Immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using PTAFR Polyclonal Antibody at dilution 1:70

Immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using PTAFR Polyclonal Antibody at dilution 1:70

Immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using PTAFR Polyclonal Antibody at dilution 1:70

PTAFR Polyclonal Antibody

E-AB-16022

Product group Antibodies

Overview

Supplier
Elabscience
Product Name
PTAFR Polyclonal Antibody
Delivery Days Customer
12
Applications Supplier
ELISA IHC
Certification
Research Use Only
Concentration
0.5mg/ml
Scientific Description
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants.
UNSPSC
12352203

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