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PTC299 [1256565-36-2]

PTC299 [1256565-36-2]

T12574
TargetMol Chemicals
CAS Number1256565-36-2
DownloadMSDS
Product group Chemicals
Estimated Purity99.19%
Molecular Weight467.34
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    PTC299 [1256565-36-2]
  • Delivery Days Customer
    9
  • CAS Number
    1256565-36-2
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    PTC299
  • Estimated Purity
    99.19%
  • Molecular Formula
    C25H20Cl2N2O3
  • Molecular Weight
    467.34
  • Scientific Description
    PTC299 ((4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate) is an orally active inhibitor of VEGFA mRNA translation and selectively inhibits VEGF protein synthesis at the post-transcriptional level. PTC299 is also a potent inhibitor of dihydrolactate dehydrogenase (DHODH).
  • Shelf life instruction
    3 years
  • SMILES
    COc1ccc(cc1)[C@@H]1N(CCc2c1[nH]c1ccc(Cl)cc21)C(=O)Oc1ccc(Cl)cc1
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties. Cao L et al., 2019 Jan, Mol Cancer Ther
    Read more

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