PTC299 [1256565-36-2]
T12574
CAS Number1256565-36-2
Product group Chemicals
Estimated Purity99.19%
Molecular Weight467.34
Overview
- SupplierTargetMol Chemicals
- Product NamePTC299 [1256565-36-2]
- Delivery Days Customer9
- CAS Number1256565-36-2
- CertificationResearch Use Only
- Chemical NamePTC299
- Estimated Purity99.19%
- Molecular FormulaC25H20Cl2N2O3
- Molecular Weight467.34
- Scientific DescriptionPTC299 ((4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate) is an orally active inhibitor of VEGFA mRNA translation and selectively inhibits VEGF protein synthesis at the post-transcriptional level. PTC299 is also a potent inhibitor of dihydrolactate dehydrogenase (DHODH).
- Shelf life instruction3 years
- SMILESCOc1ccc(cc1)[C@@H]1N(CCc2c1[nH]c1ccc(Cl)cc21)C(=O)Oc1ccc(Cl)cc1
- Storage Instruction-20°C
- UNSPSC12352200
References
- Cao L, Weetall M, Trotta C, et al. Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties. Mol Cancer Ther. 2019,18(1):3-16. doi: 10.1158/1535-7163.MCT-18-0863Read this paper
MSDS
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