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IHC-P analysis of human colon adenocarcinoma tissue using GTX83771 PTCH1 antibody [5c7]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min.
IHC-P analysis of human colon adenocarcinoma tissue using GTX83771 PTCH1 antibody [5c7]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min.
IHC-P analysis of human colon adenocarcinoma tissue using GTX83771 PTCH1 antibody [5c7]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min.

PTCH1 antibody [5c7]

GTX83771
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman
TargetPTCH1
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Overview

  • Supplier
    GeneTex
  • Product Name
    PTCH1 antibody [5c7]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500. ICC/IF: 1:100. IHC-P: 1:50. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    5c7
  • Concentration
    0.2 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID5727
  • Target name
    PTCH1
  • Target description
    patched 1
  • Target synonyms
    BCNS; NBCCS; protein patched homolog 1; PTC; PTC1; PTCH
  • Host
    Mouse
  • Isotype
    IgG2b
  • Protein IDQ13635
  • Protein Name
    Protein patched homolog 1
  • Scientific Description
    Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehogs proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Promoting roles of long non-coding RNA FAM83H-AS1 in bladder cancer growth, metastasis, and angiogenesis through the c-Myc-mediated ULK3 upregulation. Liu B et al., 2020 Dec, Cell Cycle
    Read more
  • Primary impact of Gli1 on radioresistance in esophageal cancer. Yao F et al., 2019 Nov, Oncol Lett
    Read more
  • Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex. Qi X et al., 2018 Oct 5, Science
    Read more
  • Activities of the Cytoplasmic Domains of Patched-1 Modulate but Are Not Essential for the Regulation of Canonical Hedgehog Signaling. Fleet A et al., 2016 Aug 19, J Biol Chem
    Read more