IHC-P analysis of human colon adenocarcinoma tissue using GTX83771 PTCH1 antibody [5c7]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min.
![IHC-P analysis of human endometrium adenocarcinoma tissue using GTX83771 PTCH1 antibody [5c7]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min.](https://www.genetex.com/upload/website/prouct_img/normal/GTX83771/GTX83771_1815_IHC-P_w_23061420_189.webp "IHC-P analysis of human endometrium adenocarcinoma tissue using GTX83771 PTCH1 antibody [5c7]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min.")
![IHC-P analysis of human ovary adenocarcinoma tissue using GTX83771 PTCH1 antibody [5c7]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min.](https://www.genetex.com/upload/website/prouct_img/normal/GTX83771/GTX83771_1816_IHC-P_w_23061420_216.webp "IHC-P analysis of human ovary adenocarcinoma tissue using GTX83771 PTCH1 antibody [5c7]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min.")
![IHC-P analysis of human liver carcinoma tissue using GTX83771 PTCH1 antibody [5c7]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min.](https://www.genetex.com/upload/website/prouct_img/normal/GTX83771/GTX83771_1817_IHC-P_w_23061420_862.webp "IHC-P analysis of human liver carcinoma tissue using GTX83771 PTCH1 antibody [5c7]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min.")
![IHC-P analysis of human lung carcinoma tissue using GTX83771 PTCH1 antibody [5c7]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min.](https://www.genetex.com/upload/website/prouct_img/normal/GTX83771/GTX83771_1818_IHC-P_w_23061420_363.webp "IHC-P analysis of human lung carcinoma tissue using GTX83771 PTCH1 antibody [5c7]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min.")
![IHC-P analysis of human pancreas carcinoma tissue using GTX83771 PTCH1 antibody [5c7]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min.](https://www.genetex.com/upload/website/prouct_img/normal/GTX83771/GTX83771_1819_IHC-P_w_23061420_357.webp "IHC-P analysis of human pancreas carcinoma tissue using GTX83771 PTCH1 antibody [5c7]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min.")
![IHC-P analysis of human thyroid carcinoma tissue using GTX83771 PTCH1 antibody [5c7]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min.](https://www.genetex.com/upload/website/prouct_img/normal/GTX83771/GTX83771_1820_IHC-P_w_23061420_391.webp "IHC-P analysis of human thyroid carcinoma tissue using GTX83771 PTCH1 antibody [5c7]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min.")
![IHC-P analysis of human endometrium tissue using GTX83771 PTCH1 antibody [5c7]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min.](https://www.genetex.com/upload/website/prouct_img/normal/GTX83771/GTX83771_1821_IHC-P_w_23061420_331.webp "IHC-P analysis of human endometrium tissue using GTX83771 PTCH1 antibody [5c7]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min.")
![IHC-P analysis of human kidney tissue using GTX83771 PTCH1 antibody [5c7]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min.](https://www.genetex.com/upload/website/prouct_img/normal/GTX83771/GTX83771_1822_IHC-P_w_23061420_160.webp "IHC-P analysis of human kidney tissue using GTX83771 PTCH1 antibody [5c7]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min.")
![IHC-P analysis of human pancreas tissue using GTX83771 PTCH1 antibody [5c7]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min.](https://www.genetex.com/upload/website/prouct_img/normal/GTX83771/GTX83771_1823_IHC-P_w_23061420_659.webp "IHC-P analysis of human pancreas tissue using GTX83771 PTCH1 antibody [5c7]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min.")
IHC-P analysis of human colon adenocarcinoma tissue using GTX83771 PTCH1 antibody [5c7]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min.
PTCH1 antibody [5c7]
GTX83771
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetPTCH1
Overview
- SupplierGeneTex
- Product NamePTCH1 antibody [5c7]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500. ICC/IF: 1:100. IHC-P: 1:50. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID5c7
- Concentration0.2 mg/ml
- ConjugateUnconjugated
- Gene ID5727
- Target namePTCH1
- Target descriptionpatched 1
- Target synonymsBCNS, BCNS1, NBCCS, PTC, PTC1, PTCH, SLC65B1, protein patched homolog 1
- HostMouse
- IsotypeIgG2b
- Protein IDQ13635
- Protein NameProtein patched homolog 1
- Scientific DescriptionActs as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehogs proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Liu B, Gao W, Sun W, et al. Promoting roles of long non-coding RNA FAM83H-AS1 in bladder cancer growth, metastasis, and angiogenesis through the c-Myc-mediated ULK3 upregulation. Cell Cycle. 2020,19(24):3546-3562. doi: 10.1080/15384101.2020.1850971Read this paper
- Yao F, Yu J, He Y, et al. Primary impact of Gli1 on radioresistance in esophageal cancer. Oncol Lett. 2019,18(5):4825-4833. doi: 10.3892/ol.2019.10837Read this paper
- Qi X, Schmiege P, Coutavas E, et al. Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex. Science. 2018,362(6410). doi: 10.1126/science.aas8843Read this paper
- Fleet A, Lee JP, Tamachi A, et al. Activities of the Cytoplasmic Domains of Patched-1 Modulate but Are Not Essential for the Regulation of Canonical Hedgehog Signaling. J Biol Chem. 2016,291(34):17557-68. doi: 10.1074/jbc.M116.731745Read this paper
Datasheet
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