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ProductsBack/PTPRB Antibody

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA019048ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA019048ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA019048ESR2HU at dilution of 1:100

PTPRB Antibody

CSB-PA019048ESR2HU

ApplicationsELISA, ImmunoHistoChemistry

Product group Antibodies

ReactivityHuman

TargetPTPRB

Overview

Supplier
Cusabio
Product Name
PTPRB Antibody
Delivery Days Customer
20
Applications
ELISA, ImmunoHistoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Conjugate
Unconjugated
Gene ID5787
Target name
PTPRB
Target description
protein tyrosine phosphatase receptor type B
Target synonyms
HPTP-BETA, HPTPB, PTPB, R-PTP-BETA, VEPTP, receptor-type tyrosine-protein phosphatase beta, VE-PTP, protein tyrosine phosphatase, receptor type, beta polypeptide, vascular endothelial protein tyrosine phosphatase
Host
Rabbit
Isotype
IgG
Protein IDP23467
Protein Name
Receptor-type tyrosine-protein phosphatase beta
Scientific Description
Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).
Reactivity
Human
Storage Instruction
-20°C or -80°C
UNSPSC
41116161

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