PTPRE antibody [2A9]

GeneTex

PTPRE antibody [2A9]

9

ICC/IF: 1:100. IHC-P: 1:150. FACS: 1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

2A9

0.79 mg/ml

Unconjugated

PTPRE

protein tyrosine phosphatase receptor type E

HPTPE; protein tyrosine phosphatase, receptor type, epsilon polypeptide; PTPE; receptor-type tyrosine-protein phosphatase epsilon; R-PTP-EPSILON

Mouse

IgG2b

Receptor-type tyrosine-protein phosphatase epsilon

Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function. Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake. Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+).

Human

-20°C or -80°C,2°C to 8°C

12352203