PU02

AbMole BioScience

PU02

9

313984-77-9

Chemical

Research Use Only

C16H12N4S

292.36

PU02 (NMMP) is a potent and selective negative allosteric modulator (NAM) of 5-HT3 receptor, displaying IC50 values of ~1 uM at 5-HT(3)Rs and substantially lower activities at other Cys-loop receptors. PU02 inhibits the proliferation of hepatocellular carcinoma (HepG2) cells associated with G2/M phase cell cycle arrest, and reduced cyclin-dependent kinase (CDK) 4 and cyclin B1/D1 levels.

6-[(1-naphthylmethyl)thio]-9H-purine

-20°C, sealed

12352200