WB analysis of various sample lysates using GTX29643 PUMA antibody. Loading : 20μg of lysates per lane Dilution : 3 μg/ml
WB analysis of various sample lysates using GTX29643 PUMA antibody. Loading : 20μg of lysates per lane Dilution : 3 μg/ml
PUMA antibody
GTX29643
ApplicationsImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman, Mouse
TargetBBC3
Overview
- SupplierGeneTex
- Product NamePUMA antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 2microg/ml. ICC/IF: 1microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID27113
- Target nameBBC3
- Target descriptionBCL2 binding component 3
- Target synonymsJFY-1, JFY1, PUMA, bcl-2-binding component 3, p53 up-regulated modulator of apoptosis, p53-upregulated modulator of apoptosis
- HostRabbit
- IsotypeIgG
- Protein IDQ96PG8
- Protein NameBcl-2-binding component 3, isoforms 3/4
- Scientific DescriptionThis gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Li S, Liu N, Piao J, et al. CCNB1 Expedites the Progression of Cervical Squamous Cell Carcinoma via the Regulation by FOXM1. Onco Targets Ther. 2020,13:12383-12395. doi: 10.2147/OTT.S279951Read this paper
- Keuling AM, Andrew SE, Tron VA. Inhibition of p38 MAPK enhances ABT-737-induced cell death in melanoma cell lines: novel regulation of PUMA. Pigment Cell Melanoma Res. 2010,23(3):430-40. doi: 10.1111/j.1755-148X.2010.00698.xRead this paper
Datasheet
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