Pumafentrine [207993-12-2]

MedChem Express

Pumafentrine [207993-12-2]

9

207993-12-2

Research Use Only

C29H39N3O3

477.64

Pumafentrine is an orally active, potent dual PDE3/PDE4 inhibitor. Pumafentrine dose-dependently ameliorates the clinical score and colonic TNFalpha production in murine Dextran sulphate sodium (DSS; HY-116282C)-induced colitis in a preventive setting[1].

COC1=C(OCC)C=C([C@@]2([H])[C@@](CCN(C2)C)([H])N=C3C4=CC=C(C=C4)C(N(C(C)C)C(C)C)=O)C3=C1

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