Purified Anti-Mouse TCR Oe>=/Oe Antibody

Reddot Biotech

Purified Anti-Mouse TCR Oe>=/Oe Antibody

5

Flow Cytometry

Research Use Only

Monoclonal

UC7-13D5

0.5 mg/ml

Unconjugated

Hamster

IgG

T cell receptor (TCR) is a heterodimer consisting of an Oe+/- and a beta chain (TCR Oe+/-/beta) or a Oe≥ and a Oe chain (TCR Oe≥/Oe). TCR Oe≥/Oe belongs to the immunoglobulin superfamily, involved in the recognition of certain bacterial and tumor antigens bound to MHC class I. The TCR Oe≥/Oe associates with CD3 and is expressed on a T cell subset found in the thymus, the intestinal epithelium, and the peripheral lymphoid tissues and peritoneum. Most Oe≥/Oe T cells are CD4-/CD8-, some are CD8+. T cells expressing the TCR Oe≥/Oe have been shown to play a role in oral tolerance, tumor-associated tolerance, and autoimmune disease. It has been reported that Oe≥/Oe T cells also play a principal role in antigen presentation. Immobilized UC7-13D5 antibody has been reported to activate TCR-Oe≥/Oe-bearing T cells in vitro, and to deplete peripheral TCR-Oe≥/Oe-bearing T cells in vivo.

Mouse

2°C to 8°C

12352203