Purvalanol B

MedChem Express

Purvalanol B [212844-54-7]

10

212844-54-7

Research Use Only

97.0

C20H25ClN6O3

432.90

Purvalanol B (NG 95) is a potent, selective, reversible and ATP-competitive inhibitor CDK , with IC 50 s of 6 nM, 6 nM, 9 nM, 6 nM for cdc2-cyclin B , CDK2-cyclin A , CDK2-cyclin E and CDK5-p35 , respectively. Purvalanol B shows selectivity for CDK over a range of other protein kinases (IC 50 >1000 nM). Purvalanol B inhibits the growth a chloroquine-resistant strain of P. falciparum [1] [1] .

O=C(O)C1=CC=C(NC2=C3N=CN(C(C)C)C3=NC(N[C@@H](CO)C(C)C)=N2)C=C1Cl

-20°C,2°C to 8°C

12352200