PXB17

MedChem Express

PXB17

5

Research Use Only

C29H35N7O4

545.63

PXB17 can inhibit CSF1R (IC50 = 1.7 nM) by blocking the activation of PI3K/ AKT/mTORC1 signaling. PXB17 is orally effective. PXB17 significantly inhibits the growth of CRC, improves PD-1 mAb efficacy and reduces tumor recurrence in CRC[1].

CC1=C(C(C)=C(N1)/C=C2C(NC3=C\2C=CC(NC(NC4=NOC(C(C)(C)C)=C4)=O)=C3)=O)NC(CN5CCCC5)=O

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