PYZD-4409 --- Ubiquitin-activating Enzyme (E1) Inhibitor

Bioss

PYZD-4409 --- Ubiquitin-activating Enzyme (E1) Inhibitor [423148-78-1]

16

Research Use Only

98.0

PYZD-4409 is a novel potent, selective and cell permeable inhibitor of ubiquitin-activating enzyme (E1). It induces cell death in hematologic malignant cell lines and primary patient samples preferentially over normal hematopoietic cells. PYZD-4409 blocks degradation of the short-lived proteins p53 and cyclin D3. It inhibits NF-kappaB activation and induces cell death associated with ER stress. It also displays antitumor effects in a mouse model of leukemia by intraperitoneal administration of the drug.

-20°C

51202000