PZ-2891 [2170608-82-7]

MedChem Express

PZ-2891 [2170608-82-7]

10

2170608-82-7

Research Use Only

99.68

C20H23N5O

349.43

PZ-2891 is an orally bioavailable, brain penetrant pantothenate kinase (PANK) modulator. PZ-2891 act as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits human pantothenate kinases PANK1beta, PANK2, and PANK3 with IC50s of 40.2 nM, 0.7 nM and 1.3 nM, respectively[1].

N#CC1=NN=C(N2CCN(C(CC3=CC=C(C(C)C)C=C3)=O)CC2)C=C1

-20°C,2°C to 8°C

12352200