Q94 (hydrochloride)

MedChem Express

Q94 (hydrochloride) [1052076-77-3]

14

1052076-77-3

Research Use Only

C21H18Cl2N2

369.29

Q94 hydrochloride, a selective PAR 1 antagonist ( IC 50 =916 nM), can selectively block PAR 1 / Galphaq interaction and signalling. Q94 hydrochloride blocks PAR 1 -mediated increases in both CCL2 mRNA and protein levels in a dose-dependent manner. Q94 hydrochloride also completely blocks thrombin-induced ERK1/2 and MLC phosphorylation [1] .

ClC1=CC=C(CN2C3=CC=CC=C3N=C2CC4=CC=CC=C4)C=C1.Cl

12352200