Quazinone [70018-51-8]

TargetMol Chemicals

Quazinone [70018-51-8]

44

70018-51-8

Research Use Only

Quazinone

C11H10ClN3O

235.67

Quazinone is a selective inhibitor of phosphodiesterase 3 (PDE3) with positive inotropic and vasodilating properties. It induces relaxation of precontracted isolated human cavernous smooth muscle (IC50 = 4.2 microM), increases myocardial contractile force in anesthetized open-chest dogs in a dose-dependent manner (10-300 microg/kg), decreases systolic and diastolic blood pressure, and inhibits DNA synthesis induced by the PDGF isoform PDGF-BB in bovine coronary artery smooth muscle cells in a concentration-dependent manner.

3 years

C[C@H]1N2C(NC=3C(C2)=C(Cl)C=CC3)=NC1=O

-20°C

12352200