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Quizartinib

HY-13001
MedChem Express
CAS Number950769-58-1
Product group Chemicals
Estimated Purity99.08
Molecular Weight560.67
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Quizartinib [950769-58-1]
  • Delivery Days Customer
    10
  • CAS Number
    950769-58-1
  • Certification
    Research Use Only
  • Estimated Purity
    99.08
  • Molecular Formula
    C29H32N6O4S
  • Molecular Weight
    560.67
  • Scientific Description
    Quizartinib (AC220) is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a K d of 1.6 nM. Quizartinib inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC 50 s of 4.2 and 1.1 nM, respectively. Quizartinib can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader. Quizartinib induces apoptosis [1] .
  • SMILES
    O=C(NC1=NOC(C(C)(C)C)=C1)NC2=CC=C(C=C2)C3=CN4C(SC5=CC(OCCN6CCOCC6)=CC=C45)=N3
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

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