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R-268712 [879487-87-3]

HY-12953
MedChem Express
CAS Number879487-87-3
Product group Chemicals
Estimated Purity99.92
Molecular Weight363.39
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Overview

  • Supplier
    MedChem Express
  • Product Name
    R-268712 [879487-87-3]
  • Delivery Days Customer
    10
  • CAS Number
    879487-87-3
  • Certification
    Research Use Only
  • Estimated Purity
    99.92
  • Molecular Formula
    C20H18FN5O
  • Molecular Weight
    363.39
  • Scientific Description
    R-268712 is an orally active and selective ALK-5 inhibitor, with an IC50 of 2.5 nM. R-268712 inhibits the phosphorylation of Smad3 in a dose-dependent manner with an IC50 of 10.4 nM. R-268712 suppresses glomerulonephritis as well as glomerulosclerosis by inhibiting TGF-beta signaling, which can be used in studies of renal fibrosis and cancer[1][2].
  • SMILES
    FC1=C(C2=CN(CCO)N=C2)C=C(C3=CNN=C3C4=CC=CC(C)=N4)C=C1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

MSDS

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