R-268712

MedChem Express

R-268712 [879487-87-3]

10

879487-87-3

Research Use Only

99.88

C20H18FN5O

363.39

R-268712 is an orally active and selective ALK-5 inhibitor, with an IC 50 of 2.5 nM. R-268712 inhibits the phosphorylation of Smad3 in a dose-dependent manner with an IC 50 of 10.4 nM. R-268712 suppresses glomerulonephritis as well as glomerulosclerosis by inhibiting TGF-beta signaling, which can be used in studies of renal fibrosis and cancer [1] [2] .

FC1=C(C2=CN(CCO)N=C2)C=C(C3=CNN=C3C4=CC=CC(C)=N4)C=C1

-20°C,2°C to 8°C

12352200