(R) - CR8
HY-18340
Overview
- SupplierMedChem Express
- Product Name(R) - CR8 [294646-77-8]
- Delivery Days Customer10
- CAS Number294646-77-8
- CertificationResearch Use Only
- Estimated Purity99.61
- Molecular FormulaC24H29N7O
- Molecular Weight431.53
- Scientific Description(R)?-?CR8 (CR8), a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)?-?CR8 inhibits CDK1/cyclin B ( IC 50 =0.09 microM), CDK2/cyclin A (0.072 microM), CDK2/cyclin E (0.041 microM), CDK5/p25 (0.11 microM), CDK7/cyclin H (1.1 microM), CDK9/cyclin T (0.18 microM) and CK1delta/epsilon (0.4 microM). (R)?-?CR8 induces apoptosis and has neuroprotective effect [1] [2] . (R)-CR8 acts as a molecular glue degrader that depletes cyclin K [3] .
- SMILESCC[C@@H](NC1=NC(NCC2=CC=C(C3=NC=CC=C3)C=C2)=C4N=CN(C(C)C)C4=N1)CO
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200
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