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ProductsBack/(R) - CR8 [294646-77-8]

(R) - CR8 [294646-77-8]

Research Use Only
HY-18340
MedChem Express
CAS Number294646-77-8
DownloadMSDS
Product group Chemicals
Estimated Purity99.61
Molecular Weight431.53
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Overview

  • Supplier
    MedChem Express
  • Product Name
    (R) - CR8 [294646-77-8]
  • Delivery Days Customer
    10
  • CAS Number
    294646-77-8
  • Certification
    Research Use Only
  • Estimated Purity
    99.61
  • Molecular Formula
    C24H29N7O
  • Molecular Weight
    431.53
  • Scientific Description
    (R)?-?CR8 (CR8), a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)?-?CR8 inhibits CDK1/cyclin B (IC50=0.09 microM), CDK2/cyclin A (0.072 microM), CDK2/cyclin E (0.041 microM), CDK5/p25 (0.11 microM), CDK7/cyclin H (1.1 microM), CDK9/cyclin T (0.18 microM) and CK1delta/epsilon (0.4 microM). (R)?-?CR8 induces apoptosis and has neuroprotective effect[1][2]. (R)-CR8 acts as a molecular glue degrader that depletes cyclin K[3].
  • SMILES
    CC[C@@H](NC1=NC(NCC2=CC=C(C3=NC=CC=C3)C=C2)=C4N=CN(C(C)C)C4=N1)CO
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200