(R)-DRF053 (dihydrochloride)

MedChem Express

(R)-DRF053 (dihydrochloride)

5

1241675-76-2

Research Use Only

99.30

C23H29Cl2N7O

490.43

(R)-DRF053 dihydrochloride is a potent casein kinases 1 (CK1), CDK1/cyclin B and CDK5/p25 inhibitor with IC50s of 14 nM, 220 nM and 80 nM, respectively. (R)-DRF053 dihydrochloride prevents the CK1-dependent production of amyloid-beta in a cell model[1].

CC(C)N1C2=NC(N[C@@H](CO)CC)=NC(NC3=CC(C4=CC=CC=N4)=CC=C3)=C2N=C1.Cl.Cl

2°C to 8°C

12352200