(R)-Elexacaftor [2229860-99-3]

MedChem Express

(R)-Elexacaftor [2229860-99-3]

14

2229860-99-3

Research Use Only

99.44

C26H34F3N7O4S

597.65

(R)-Elexacaftor is an enantiomer of Elexacaftor (HY-111772). (R)-Elexacaftor is the Compound 37 from patent WO2018107100A1. (R)-Elexacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR), the EC50 for CFTR dF508 is 0.29 uM[1].

CC1(C)C[C@@H](C)CN1C2=C(C(NS(C3=CN(C)N=C3C)(=O)=O)=O)C=CC(N4C=CC(OCC(C)(C(F)(F)F)C)=N4)=N2

-20°C,2°C to 8°C

12352200