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Chemical Structure
Chemical Structure
Chemical Structure

(R)-FSL-1

Research Use Only
AG-CP3-0010
AdipoGen Life Sciences
Molecular Weight1666.2
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Product group Chemicals
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    (R)-FSL-1
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Molecular Formula
    C84H140N14O18S
  • Molecular Weight
    1666.2
  • Scientific Description
    Chemical. Formula: C84H140N14O18S. MW: 1666.2. Synthetic. R-FSL-1 (R-Pam2CGDPKHPKSF) is a synthetic lipoprotein that represents the N-terminal part of the 44kDa lipoprotein LP44 of Mycoplasma salivarium. The naturally occurring R-stereoisomer is biologically more active than the S-stereoisomer. Stimulator of TLR2/TLR6. Inducer of TNF-alpha production in macrophages. Upregulates proinflammatory cytokines. Activator of the proinflammatory transcription factor NF-kappaB. - R-FSL-1 (R-Pam2CGDPKHPKSF) is a synthetic lipoprotein that represents the N-terminal part of the 44kDa lipoprotein LP44 of Mycoplasma salivarium [1]. The naturally occurring R-stereoisomer is biologically more active than the S-stereoisomer [4]. Stimulator of TLR2/TLR6 [2-13]. Inducer of TNF-alpha production in macrophages [5]. Upregulates proinflammatory cytokines [3,5]. Activator of the proinflammatory transcription factor NF-kappaB [3].
  • SMILES
    [H][C@@](COC(=O)CCCCCCCCCCCCCCC)(CSC[C@]([H])(N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O)OC(=O)CCCCCCCCCCCCCCC
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • The N-terminal lipopeptide of a 44-kDa membrane-bound lipoprotein of Mycoplasma salivarium is responsible for the expression of intercellular adhesion molecule-1 on the cell surface of normal human gingival fibroblasts: K.I. Shibata, et al.; J. Immunol. 165, 6538 (2000)
  • Discrimination of bacterial lipoproteins by Toll-like receptor 6: O. Takeuchi, et al.; Int. Immunol. 13, 933 (2001)
  • Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by Toll-Like Receptors 2 and 6: T. Okusawa, et al.; Infect. Immun. 72, 1657 (2004)
  • Involvement of suppressors of cytokine signaling in toll-like receptor-mediated block of dendritic cell differentiation: H. Bartz, et al.; Blood 108, 4102 (2006)
  • Effects of repeated injections of fibroblast-stimulating lipopeptide-1 on fever, formation of cytokines, and on the responsiveness to endotoxin in guinea-pigs: A. Greis, et al.; Acta Physiol. 197, 35 (2009)
  • Regulators of G-protein signalling are modulated by bacterial lipopeptides and lipopolysaccharide: S. Riekenberg, et al.; FEBS J. 276, 649 (2009)
  • Toll-like receptors and innate immunity: H. Kumar, et al.; BBRC 388, 621 (2009)
  • Lipoteichoic Acid Induces Unique Inflammatory Responses when Compared to Other Toll-Like Receptor 2 Ligands: E.M. Long, et al.; PLoS One 4, e5601 (2009)
  • A new cell-based innate immune receptor assay for the examination of receptor activity, ligand specificity, signalling pathways and the detection of pyrogens: A. Burger-Kentischer, et al.; J. Immunol. Methods 358, 93 (2010)
  • Toll-like receptor 2 (P631H) mutant impairs membrane internalization and is a dominant negative allele: G.E. Etokebe, et al.; Scand. J. Immunol. 71, 369 (2010)