(R)-MRT199665
HY-120877A
Estimated Purity98.70
Product group Chemicals
Molecular Weight469.58
Overview
- SupplierMedChem Express
- Product Name(R)-MRT199665
- Delivery Days Customer9
- CertificationResearch Use Only
- Estimated Purity98.70
- Molecular FormulaC28H31N5O2
- Molecular Weight469.58
- Scientific Description(R)-MRT199665 is an isomer of MRT199665 (HY-120877). MRT199665 is a potent and ATP-competitive, selective MARK/SIK/AMPK inhibitor with IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKalpha1/AMPKalpha2, and SIK1/SIK2/SIK3, respectively. MRT199665 causes apoptosis in MEF2C-activated human acute myeloid leukemias (AML) cells. MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370[1][2][3].
- SMILESO=C1C(C)(C)C2=CN=C(NC3=CC=CC(CN4CCCC4)=C3)N=C2N1[C@@H]5CCC6=C5C=CC=C6O
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200