(R)-STU104-d6 [3063042-81-6]

MedChem Express

(R)-STU104-d6 [3063042-81-6]

102

3063042-81-6

Research Use Only

99.90

C18H12D6O4

304.37

(R)-STU104-d6 is a deuterium labeled (R)-STU104 (HY-150612). (R)-STU104 is a potent and orally active TAK1-MKK3 interaction inhibitor with IC50s of 0.58 microM and 4.0 microM for TNF-alpha and MKK3 phosphorylation. (R)-STU104 suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signal pathways through binding with MKK3 and disrupting the TAK1 phosphorylating MKK3. (R)-STU104 can be used for researching ulcerative colitis[1].

O=C1C2=CC(OC([2H])([2H])[2H])=CC(OC([2H])([2H])[2H])=C2[C@@H](C3=CC=C(OC)C=C3)C1

-20°C,2°C to 8°C

12352200