(R)-Thionisoxetine (hydrochloride) [222961-65-1]

MedChem Express

(R)-Thionisoxetine (hydrochloride) [222961-65-1]

9

222961-65-1

Research Use Only

C17H22ClNOS

323.88

(R)-Thionisoxetine hydrochloride (LY-368975 hydrochloride) is a potent and selective central and peripheral norepinephrine (NE) uptake inhibitor. (R)-Thionisoxetine hydrochloride prevents 6-hydroxydopamine-induced hypothalamic NE depletion with an ED50 of 0.21 mg/kg. (R)-Thionisoxetine hydrochloride can be used in the study of a variety of diseases, including depression and urinary incontinence[1].

CSC1=CC=CC=C1O[C@@H](C2=CC=CC=C2)CCNC.Cl

12352200