R1498 [303196-31-8]
HY-119618
CAS Number303196-31-8
Product group Chemicals
Molecular Weight338.79
Overview
- SupplierMedChem Express
- Product NameR1498 [303196-31-8]
- Delivery Days Customer9
- CAS Number303196-31-8
- CertificationResearch Use Only
- Molecular FormulaC18H15ClN4O
- Molecular Weight338.79
- Scientific DescriptionR1498 is a multi-target kinase inhibitor with anti-angiogenic and anti-proliferative activities. R1498 mainly targets targets such as Aurora kinase and VEGFR2, which are associated with tumor development. R1498 showed moderate in vitro growth inhibition in a variety of tumor cells, with IC50 values in the micromolar range. R1498 showed anti-tumor efficacy superior to sorafenib in a variety of gastric cancer and hepatocellular carcinoma xenograft models, with tumor growth inhibition rates exceeding 80%, and tumor shrinkage was observed in some models. R1498 showed a 10-30% tumor shrinkage rate in three xenograft models derived from human primary gastric cancer tumors, further demonstrating its inhibitory potential. R1498 effectively inhibited Aurora A activity in vivo and reduced tumor vascularization[1].
- SMILESClC1=C(C2=NC3=C(C)NN=C3NC4=C2C=C(OC)C=C4)C=CC=C1
- UNSPSC12352200